Chihiro Tohda Selected Research

denosomin

1/2016	Extracellular vimentin is a novel axonal growth facilitator for functional recovery in spinal cord-injured mice.
12/2015	Synthesis of Denosomin-Vitamin D3 Hybrids and Evaluation of Their Anti-Alzheimer's Disease Activities.
2/2013	A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin.
9/2009	Synthesis of sominone and its derivatives based on an RCM strategy: discovery of a novel anti-Alzheimer's disease medicine candidate "denosomin".

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Chihiro Tohda Research Topics

Disease

30	Alzheimer Disease (Alzheimer's Disease) 09/2022 - 11/2003
16	Atrophy 12/2021 - 05/2004
13	Memory Disorders (Memory Loss) 12/2021 - 04/2005
11	Spinal Cord Injuries (Spinal Cord Injury) 11/2020 - 06/2007
4	Dementia (Dementias) 09/2022 - 03/2006
4	Amyloid Plaque 01/2018 - 04/2011
4	Neuroblastoma 05/2004 - 06/2002
3	Neuroinflammatory Diseases 12/2021 - 04/2011
3	Gliosis 02/2013 - 06/2007
2	Cognitive Dysfunction 12/2021 - 05/2004
2	Inflammation (Inflammations) 02/2021 - 06/2006
2	Cicatrix (Scar) 01/2018 - 02/2013
2	Contusions 01/2018 - 01/2012
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2014 - 08/2008
2	Body Weight (Weight, Body) 06/2007 - 12/2005
1	Mental Disorders (Mental Disorder) 09/2022
1	Muscular Atrophy (Muscle Atrophy) 01/2019
1	Weight Loss (Weight Reduction) 01/2019
1	Frailty 01/2014
1	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2014
1	Psychomotor Agitation (Akathisia) 01/2009
1	Fibrosis (Cirrhosis) 04/2007
1	Renal Insufficiency (Renal Failure) 04/2007
1	Diabetes Mellitus 09/2006
1	Arthritis (Polyarthritis) 06/2006
1	Experimental Arthritis 06/2006

Drug/Important Bio-Agent (IBA)

10	Amyloid (Amyloid Fibrils)IBA 09/2022 - 07/2008
5	Pharmaceutical PreparationsIBA 01/2018 - 11/2003
5	withanoside IVIBA 08/2009 - 06/2002
4	kamikihi-to (KKT)IBA 01/2019 - 12/2011
4	DiosgeninIBA 01/2018 - 01/2012
4	denosominIBA 01/2016 - 09/2009
4	sominoneIBA 04/2011 - 03/2006
3	AshwagandhaIBA 01/2014 - 10/2002
3	Methanol (Carbinol)IBA 07/2011 - 10/2002
2	MatrinesIBA 11/2019 - 01/2018
2	Chondroitin Sulfate ProteoglycansIBA 01/2018 - 01/2015
2	SteroidsIBA 01/2018 - 12/2015
2	icariinIBA 01/2012 - 11/2010
2	eleutheroside EIBA 07/2011 - 07/2008
2	syringinIBA 07/2011 - 07/2008
2	isofraxidinIBA 07/2011 - 07/2008
2	3- rhamnopyranosyl(1- 4)- glucopyranosyl- 12- diacetoxy- 20- hydroxywitha- 5,24- dienolideIBA 08/2008 - 06/2002
2	protopanaxadiolIBA 06/2006 - 05/2004
2	ginsenoside M1IBA 06/2006 - 05/2004
2	Amyloid beta-PeptidesIBA 06/2006 - 01/2005
2	SaponinsIBA 06/2006 - 05/2004
1	N-acetylaspartate (N-acetyl aspartate)IBA 09/2022
1	EnzymesIBA 09/2022
1	Proteins (Proteins, Gene)FDA Link 09/2022
1	HemopexinIBA 12/2021
1	Messenger RNA (mRNA)IBA 12/2021
1	Lipocalin-2IBA 12/2021
1	Placental ExtractsIBA 05/2021
1	Neuroprotective AgentsIBA 02/2021
1	Pyruvate KinaseIBA 11/2020
1	Protein Isoforms (Isoforms)IBA 11/2020
1	trigonellineIBA 10/2020
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 11/2019
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019
1	acteosideIBA 01/2019
1	MyokinesIBA 01/2019
1	Growth InhibitorsIBA 01/2018
1	VER 155008IBA 01/2018
1	Cholecalciferol (Vitamin D3)FDA Link 12/2015
1	Carrier Proteins (Binding Protein)IBA 12/2015
1	caffeic acidIBA 09/2015
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2014
1	Protein Phosphatase 2 (Protein Phosphatase 2A)IBA 01/2014
1	Proteoglycans (Proteoglycan)IBA 02/2013
1	VimentinIBA 02/2013
1	ChondroitinIBA 02/2013
1	Hydroxyl RadicalIBA 01/2012
1	Neutralizing AntibodiesIBA 01/2012
1	ethyl acetateIBA 07/2011
1	1-Butanol (n Butanol)IBA 07/2011
1	Chloroform (Trichloromethane)IBA 01/2011
1	Plant ExtractsIBA 11/2010
1	Peptides (Polypeptides)IBA 08/2009
1	Phosphotransferases (Kinase)IBA 01/2009
1	calpastatinIBA 08/2008
1	guibi-tangIBA 08/2008
1	CalpainIBA 08/2008
1	Myelin Basic ProteinIBA 08/2008
1	Methylprednisolone FDA LinkGeneric 06/2007
1	gamma-Aminobutyric Acid (GABA)IBA 04/2007
1	Dihydrotachysterol (AT 10)IBA 04/2007
1	PolyphenolsIBA 09/2006
1	Cholinergic Agents (Cholinergics)IBA 09/2006
1	DiarylheptanoidsIBA 06/2006
1	HaptoglobinsIBA 06/2006

Therapy/Procedure

5	Therapeutics 01/2021 - 06/2007
4	Oral Administration 05/2021 - 03/2006
3	Kampo Medicine (Kampo) 01/2019 - 11/2003
1	Intramuscular Injections 01/2019
1	Laminectomy 01/2012
1	Cell Transplantation 01/2012
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 08/2008
1	Nephrectomy 04/2007
1	Traditional Medicine (Folk Remedies) 09/2006